Atypical fibroxanthoma (AFX) is a nodular dermal ulcerative lesion with a favorable prognosis. AFX most commonly occurs on sun-exposed skin in elderly individuals.

Atypical fibroxanthoma usually stains for CD10 and is negative for the markers of cutaneous squamous cell carcinoma, melanoma, angiosarcoma and leiomyosarcoma. Frequently only CD10 is positive. Most atypical fibroxanthomas are benign, provided that strict criteria are used for diagnosis.

Despite its classical benign behavior some rare cases reporting distant metastasis classified it on intermediate malignancy. Atypical Fibroxanthoma - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version. Atypical fibroxanthoma (AFX) is a nodular dermal ulcerative lesion with a favorable prognosis. AFX most commonly occurs on sun-exposed skin in elderly individuals. AFX is characterized by its assoc Atypical fibroxanthoma (AFX) is a nodular dermal ulcerative lesion with a favorable prognosis. AFX most commonly occurs on sun-exposed skin in elderly individuals.

Atypical fibroxanthoma prognosis

Atypical fibroxanthoma is a low-grade sarcoma of the skin. (See also Overview of Skin Cancer.) Atypical fibroxanthomas are rare among nonmelanoma skin cancers. They most commonly occur on the head and neck of older patients. Atypical fibroxanthoma (AFX) is a nodular dermal ulcerative lesion with a favorable prognosis. AFX most commonly occurs on sun-exposed skin in elderly individuals. Atypical fibroxanthoma presents as a dermally based, circumscribed lesion with overlying epidermal collarette, central ulceration, and parakeratosis (Figure 1, A and B). Mild to severe solar elastosis is regularly encountered adjacent to the tumor. Atypical fibroxanthoma (AFX) was first reported by Helwig in the early 1960s .

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A rare type of atypical fibroxanthoma occurs in younger patients on parts of the body that are not normally overexposed to the sun. Atypical fibroxanthoma prognosis. Atypical fibroxanthoma rarely recurs after complete excision with clear margins.

Oct 14, 2020 Atypical fibroxanthoma (AFX) is a tumor that occurs primarily in older individuals after the skin of the head and neck has been damaged

Metastasis is rare, but when it occurs, the lymph nodes are often the first site of involvement. Atypical fibroxanthoma (AFX) is a tumor that occurs primarily in older individuals after the skin of the head and neck has been damaged significantly by sun exposure and/or therapeutic radiation. Histologically similar to atypical fibroxanthoma but larger and shows substantial involvement of the subcutis or beyond, perineural invasion, lymphovascular invasion or necrosis Behaves in a more aggressive manner than atypical fibroxanthoma Melanoma: Usually associated with an in situ component in the overlying epidermis Treatment of atypical fibroxanthoma of the skin (AFX) includes curettage and dessication (C&D), wide local excision (WLE), and Mohs micrographic surgery (MMS). Although all three are within the standard of care, the same Mayo clinic review found significant differences in recurrence rates. With Mohs micrographic surgery the recurrence was 0%, and with wide local excision it was 8.7%.

Atypical fibroxanthoma (AFX) is a tumor that occurs primarily in older individuals after the skin of the head and neck has been damaged significantly by sun exposure and/or therapeutic radiation. Histologically similar to atypical fibroxanthoma but larger and shows substantial involvement of the subcutis or beyond, perineural invasion, lymphovascular invasion or necrosis Behaves in a more aggressive manner than atypical fibroxanthoma Melanoma: Usually associated with an in situ component in the overlying epidermis Abstract Background: Atypical fibroxanthoma (AFX) is an uncommon, rapidly growing cutaneous neoplasm of uncertain histogenesis.
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• Atypical fibroxanthoma (AFX).

Microscopically, it is characterized by the presence of highly atypical cytologic features, pleomorphism and abundant mitotic figures. The vast majority of patients have an excellent prognosis following conservative therapy.
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An atypical fibroxanthoma is a rare, malignant fibrohistiocytic neoplasm, which develops most commonly on the sun-exposed skin of elderly individuals. It has invasive potential, may recur locally after excision, and very rarely metastasizes. This chapter is set out as follows:

AFX is now generally regarded as the superficial counterpart of undifferentiated pleomorphic sarcoma (so-called malignant Atypical fibroxanthoma (AFX) is a dermal mesenchymal neoplasm arising in sun-damaged skin, primarily of the head and neck region of older men. Conservative excision cures most. However, varying degrees of subcutaneous involvement can lead to a more aggressive course and rare metastases. Se hela listan på dermatologyadvisor.com Atypical fibroxanthomas might be detected as a nodular skin lesion of some millimetres up to some centimetres on ultrasound, CT or MRI. After administration of a contrast agent, it has been described to show enhancement. Treatment and prognosis. Atypical fibroxanthomas are surgically removed and have a good prognosis.